Effect of Starch Hydrolysates in the Process of Dissolution of Solids
Belniak, P.; Świąder, K.; Szumiło, M.ł; Pietrzyk, E.; Poleszak, E.
Acta Poloniae Pharmaceutica 72(4): 785-789
2015
ISSN/ISBN: 0001-6837 PMID: 26647636 Document Number: 685734
The purpose of this work was to investigate the influence of starch hydrolysates in the dissolution process of the substance practically insoluble in water. Progesterone and ibuprofen were chosen as model substances. The study was conducted with a constant amount of the drug (25 mg/mL) or constant amount of starch hydrolysate (50 mg/mL). Next, the influence of ethanolic solutions (10-30% v/v) on solubility of drug was tested. The results confirm the possibility of using starch hydrolysate as a cheap and safe addition to increase the solubility of practically insoluble drugs.