Top Abstract Purchase Related
Home
>
Node
>
Subnode

On the lacking teratogenic effect of the plasmaexpander hydroxyethyl starch in the rat and mouse

Ivankovic, S.; Bülow, I.

Der Anaesthesist 24(5): 244-245

1975

ISSN/ISBN: 0003-2417
PMID: 56907
Document Number: 94718
Hydroxyethyl-starch (HES) has been tested for teratogenic activity in BD-strain rats and Swiss mice. HES in both species was shown not to be teratogenic. High doses of 50 g/kg/day given by intraperitoneal injection lead to abortion in all pregnant rats. This report in concerned with the important question of, whether development and normal life of the progeny of rats and mice is affected when treated with HES during pregnancy. Special attention has been given to potential teratogenic effects.

Document emailed within 1 workday
Secure & encrypted payments

Jamnicki, M.; Zollinger, A.; Seifert, B.; Popovic, D.; Pasch, T.; Spahn, D.R. 1998: Compromised blood coagulation: an in vitro comparison of hydroxyethyl starch 130/0.4 and hydroxyethyl starch 200/0.5 using thrombelastography Anesthesia and Analgesia 87(5): 989-993
Pi, Z.-b.; Tan, G.-x.; Wang, J.-l. 2007: Effect of hydroxyethyl starch 130/0.4 on S100B protein level and cerebral oxygen metabolism in open cardiac surgery under cardiopulmonary bypass Zhonghua Yi Xue Za Zhi 87(27): 1908-1911
Gahr, R.; Bock, P.R. 1981: Effect of hydroxyethyl starch HES 450/0.7 and 5% human albumin on the colloid osmotic pressure and hemodynamic parameters in hypovolemic patients after major abdominal procedures Infusionstherapie und Klinische Ernahrung 8(3): 147-152
Ikeda, K.; Tanaka, S.; Mizutani, H.; Horii, D.; Arai, Y. 1971: Effect of hydroxyethyl starch on blood volume and extracellular fluid volume during hemorrhage--comparison with the effect of clinical dextran and re-infusion of autologous blood Masui. Japanese Journal of Anesthesiology 20(7): 639-647
Kitamura, Y.; Yamada, A.; Sha, N.; Hamanaka, R.; Nishimura, K. 1972: Hespander (hydroxyethyl starch) Masui. Japanese Journal of Anesthesiology 21(11): 1121-1133
Kitamura, Y.; Yamada, A.; Sha, N.; Hamai, R.; Nishimura, K. 1972: A clinical study of hydroxyethyl starch Osaka City Medical Journal 18(1): 21-36
Meister, D.; Hermann, M.; Mathis, G.A. 1992: Kinetics of hydroxyethyl starch in horses Schweizer Archiv für Tierheilkunde 134(7): 329-339
Treib, J.; Haass, A.; Pindur, G. 1997: Coagulation disorders caused by hydroxyethyl starch Thrombosis and Haemostasis 78(3): 974-983
Fiala, J. 1979: Use of hydroxyethyl starch in blood transfusion and hematology Vnitrni Lekarstvi 25(9): 897-902
Köhler, H.; Kirch, W.; Vogt, J.; Höffler, D. 1977: Pharmacokinetics of hydroxyethyl starch in kidney failure Verhandlungen der Deutschen Gesellschaft für Innere Medizin 83: 1676-1678
Kościelak, J.; Gryszkiewicz, A.; Schier, J.; Góralski, S. 1977: Fate of C-14 labeled hydroxyethyl starch in mice Acta Haematologica Polonica 8(4): 303-307
Mishler, J.M. 1980: Pharmacokinetics of middle-molecular hydroxyethyl starch (HAS 200/0,5 Infusionstherapie und Klinische Ernahrung 7(2): 96-102
Daszyński, J.; Gryszkiewicz, A.; Kościelak, J. 1976: Erythrocyte freezing in the presence of hydroxyethyl starch Acta Haematologica Polonica 7(2): 155-161
Hayashi, K.; Higashi, H. 1975: Clinical comparison of plasma substitutes, dextran and hydroxyethyl starch Masui. Japanese Journal of Anesthesiology 24(9): 853-859
Oda, A.; Aoki, A.; Ozaki, T.; Unno, K.; Nagai, N. 1972: Behavior of hydroxyethyl starch in the plasma and urine of man following intravenous infusion Masui. Japanese Journal of Anesthesiology 21(8): 747-753
Jesch, F.; Hübner, G.; Zumtobel, V.; Zimmermann, M.; Messmer, K. 1979: Hydroxyethyl starch (HAS 450/0.7) in human plasma and liver. Course of concentration and histological changes Infusionstherapie und Klinische Ernahrung 6(2): 112-117
Vinazzer, H.; Bergmann, H. 1975: The influence of hydroxyethyl starch on postoperative alterations of blood coagulation Der Anaesthesist 24(12): 517-520
Weidler, B.; von Bormann, B.; Sommermeyer, K.; Lohmann, E.; Peil, J.; Hempelmann, G. 1991: Pharmacokinetic parameters as criteria for clinical use of hydroxyethyl starch preparations Arzneimittel-Forschung 41(5): 494-498
Howden, B.O.; Jablonski, P.; Thomas, A.C.; Walls, K.; Biguzas, M.; Scott, D.F.; Grossman, H.; Marshall, V.C. 1990: Liver preservation with UW solution. I. Evidence that hydroxyethyl starch is not essential Transplantation 49(5): 869-872
Boldt, J.; von Bormann, B.; Kling, D.; Börner, U.; Mulch, J.; Hempelmann, G. 1986: Volume replacement with a new hydroxyethyl starch preparation (3 percent HES 200/0.5) in heart surgery Infusionstherapie und Klinische Ernahrung 13(3): 145-151