Molecular Karyotyping of Cell-Free DNA from Blastocoele Fluid as a Basis for Noninvasive Preimplantation Genetic Screening of Aneuploidy

Skryabin, N.A.; Lebedev, I.N.; Artukhova, V.G.; Zhigalina, D.I.; Stepanov, I.A.; Krivoschekova, G.V.; Svetlakov, A.V.; Skryabin, N.A; Lebedev, I.N; Artukhova, V.G; Zhigalina, D.I; Stepanov, I.A; Krivoschekova, G.V; Svetlakov, A.V

Home

>

Node

>

Subnode

Molecular Karyotyping of Cell-Free DNA from Blastocoele Fluid as a Basis for Noninvasive Preimplantation Genetic Screening of Aneuploidy

Skryabin, N.A.; Lebedev, I.N.; Artukhova, V.G.; Zhigalina, D.I.; Stepanov, I.A.; Krivoschekova, G.V.; Svetlakov, A.V.

Genetika 51(11): 1301-1307

2015

ISSN/ISBN: 0016-6758

PMID: 26845860

Document Number: 685488

The discovery of DNA fragments in the blastocoele fluid is promising for the development of new noninvasive methods for the preimplantation genetic diagnosis of chromosomal diseases. However, to date there are no data confirming the concordance between the molecular karyotype of cell-free DNA from blastocoele fluid and the blastocyst cells per se. This paper reports on this concordance according to the results of molecular-cytogenetic analysis of the chromosomal set with the use of comparative genomic hybridization.