A molecular basis for T-dependent B cell activation
Lane, P.
Behring Institute Mitteilungen 1995(96): 7-12
1995
ISSN/ISBN: 0301-0457 PMID: 7575354 Document Number: 449613
This review has concentrated on the key molecules which regulate T-dependent B cell activation in the context of the structural architecture within secondary lymphoid tissue where B cell immune responses occur. CD40L clearly plays a key role in driving B cells to proliferate within germinal centers, and although the data is conflicting, there is some evidence that the induction of CD40L is dependent on costimulation through CD28.
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