Molecular cloning of the NK1.1 antigen, a member of the NKR-P1 family of natural killer cell activation molecules
Ryan, J.C.; Turck, J.; Niemi, E.C.; Yokoyama, W.M.; Seaman, W.E.
Journal of Immunology 149(5): 1631-1635
1992
ISSN/ISBN: 0022-1767 PMID: 1506685 Document Number: 391914
In mice, the NK1.1 alloantigen is expressed on all natural killer cells, and initiates transmembrane signals that activate cytotoxicity. NK1.1 has been mapped to a chromosomal region that encodes 2 families of receptor-like molecules, the NKR-P1 family and the Ly-49 family. Both of these gene families encode type II integral membrane proteins whose extracellular domains are homologous with known C-type lectins. A member of the NKR-P1 gene family (mNKR-P1.9) was isolated and sequenced, and it was demonstrated by immunofluorescence and immunoprecipitation that this cDNA encodes NK1.1.