Dynamics of Apoptotic Markers (Interleukin-2 and Tnf-Α) in the Blood Serum of Children with Chronic Gastroduodenites
Reuka, E.Y.; Trifonov, V.D.; Chernenkov, Y.V.; Rodionova, T.V.
Eksperimental'naia i Klinicheskaia Gastroenterologiia 1: 21-23
2015
ISSN/ISBN: 1682-8658 PMID: 26281156 Document Number: 685468
The aim was to investigate apoptotic dynamics by IL-2 and TNF-α levels in the blood serum of children with chronic gastroduodenites. There were examined 90 children with chronic gastroduodenitis. Cytokine level in the serum was studied at admission and in dynamics. Chronic gastroduodenitis is accompanied by the increase of IL-2 and TNF-α concentration thus reflecting the activity of apoptotic processes. The decrease of the markers' (IL-2 and TNF-α) levels after 10-11 days, 3 and 9 months after treatment indicates the decrease of apoptotic activity. In hyperplastic and atrophic gastritis there has been registered the highest and the lowest concentration of the markers, respectively. H. pylori contributes to the TNF-α production mainly.