Hypercapnia--alternative hypoxia signal incentives to increase HIF-1α and erythropoietin in the brain
Kulikov, V.P.; Tregub, P.P.; Kovzelev, P.D.; Dorokhov, E.A.; Belousov, A.A.
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 3: 34-37
2015
ISSN/ISBN: 0031-2991 PMID: 26852593 Document Number: 685332
Investigated the role of hypercapnic component in the mechanism of activation of HIF-1α and increase the synthesis of erythropoietin in the combined and the isolated impact of hypoxia and hypercapnia. It was found that the content of proteins of interest significantly increases both in isolated hypoxia and hypercapnia, and at their combined effect. Moreover, the hypercapnic hypoxia causes maximum activation of the synthesis and accumulation of erythropoietin HIF-1α, and permissive hypercapnia enhances their content more than hypoxic exposure.