Links between glycolysis and DNA replication in eukaryotic cells
Konieczna, A.; Łyżeń, R.; Węgrzyn, G.
Postepy Biochemii 61(4): 444-460
2015
ISSN/ISBN: 0032-5422 PMID: 27048099 Document Number: 684301
Development of the eukaryotic cell proceeds through sequentional stages of the cell cycle, in which there are growth, replication of the genetic material, and cell division processes. Many environmental and intracellular factor decides if the cell proceeds throughout all stages of the cell cycle or enters the G₀ silencing phase. The cell cycle depends also on metabolic processes, including central carbon metabolism and DNA replication. One cof major processes of the central carbon metabolism is glycolysis. This is the main pathway of glucose metabolism in cells, leading to conversion of this molecule to puryvare. Until recently, it was supposed that carbon metabolism and DNA replication are linked only indirectly, mostly through energy input, necessary for synthesis of nucleic acids, and production of precursors of deoxyribonucleotides. Nevertheless, recent studies, described and discussed in this article, suggested that there are much more complicated links, perhaps also direct, between these two processes.