The effect of substituted aminoalkylaminoanthraquinones on eukaryotic cells
Katzhendler, J.; Bar-Ad, G.; Haran, M.; Gean, K.F.; Tashma, Z.; Ringel, I.; Ramu, A.; Bachrach, U.
Drug Design and Delivery 4(4): 289-294
1989
ISSN/ISBN: 0884-2884 PMID: 2775448 Document Number: 345838
Nine aminoalkylaminoanthraquinones (I-IX) were evaluated for their cytotoxic potency against normal and malignant mammalian cells. The 1.8-di-(aminopropylamino) derivative (VIII) exhibited significant activity against several tumor cell systems and had some selectivity. The toxicity of this compound was also tested in growing chick embryos.