Comprehensive Assessment of the Hemostasis System in Test-Subjects in Experiment "mars-500"
Kuzichkin, D.S.; Markin, A.A.; Vorontsov, A.L.; Morukov, B.V.; Zhuravleva, O.A.; Zabolotskaia, I.V.; Vostrikova, L.V.
Aviakosmicheskaia i Ekologicheskaia Meditsina 49(3): 19-24
2015
ISSN/ISBN: 0233-528X PMID: 26292421 Document Number: 683900
The paper is devoted to the hemostasis studies in the course of long-term (520 d) isolation in an airtight chamber. Measured parameters included activated partial thromboplastin time (APTT), international normalized ratio (INR), thrombin time (TT); concentrations of fibrinogen (FBG), plasminogen (PG), Willebrand factor (WF), tissue factor pathway inhibitor (TFPI), and tissue plasminogen activator (TPA), thrombomodulin (TM); activities of the coagulation cascade factors (II, V, VII, X, VIII, IX, XI, XII), antithrombin III (ATIII), protein C (PC), C1-inhibitor (C1), α2-antiplasmin (AP), TPA and TFPI. The investigation revealed a diversity of changes in the plasma fibrinogen concentration, slower blood coagulation in the intrinsic pathway and the final stage, and a relative rise in the activities of ATIII and PC-inhibited factors. The rest parameters showed different trends.