Tobacco smoking as a cofactor for the development of cervical cancer
Jabłonowska-Fudzińska, D.; Marszałek, A.; Szylberg, Łukasz.
Przeglad Lekarski 72(3): 103-105
2015
ISSN/ISBN: 0033-2240 PMID: 26731863 Document Number: 680202
Etiopathogenesis of cervical cancer is mainly related to persistent HPV infection. However in neoplastic transformation participate additional factors, one of the main is tobacco smoking. Nowadays, in Poland is conduced prophylactic program with the target to decrease incidence and mortality according to cervical cancer. The basis of this program is Pap smears, histological diagnostics and colposcopy. The aim of this paper was evaluation of correlation between histopatological changes uterin cervix in respect of tobacco smoking and immunohistochemistry LI capsid protein test. From 3520 patients with incorrect Pap smears selected 36 cases (medium age 36) with incorrect Pap smears and histology. Used immunohistochemical methods (with HRP system) for evaluation of L1 protein. In group with positive L1 test significant part were smokers and those who quite smoking. The results revealed directly relate between cigarette.