Human papilloma virus and cervical cancer. An historical review on the development of research on cancer of the cervix uteri in Venezuela
García-Tamayo, J.; Molina, J.; Blasco-Olaetxea, E.; Núñez Montiel, J.é T.
Investigacion Clinica 51(2): 193-208
2010
ISSN/ISBN: 0535-5133 PMID: 20928978 Document Number: 12946
The history on the relationship of VPH infection and cervical cancer was examined. Findings were initially reported in Maracaibo(1971), later in Mexico(1973) and thereafter several studies on the ultrastructure and immunohistochemistry of VPH infection and its role on cervical cancer were described. The ultrastructural findings of viral particles of HPV and their proteins, as well as their role in the incorporation of the viral genome to the human cervical cells were also described. Glycoproteins on the surface of cervical cells were reviewed and their importance on HPV infection was related to p16, blood group antigens and early genetic changes in the cell cycle with loss of heterozigocity, all of which, stimulated by the high risk HPV infection lead to cervical cancer.
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