Effectiveness of radiotherapy of patients with cancer of the cervix uteri at the Central Research Roentgeno-Radiological Institute of the USSR Ministry of Health
Kholin, V.V.; Zharinov, G.M.
Voprosy Onkologii 35(12): 1476-1479
1989
ISSN/ISBN: 0507-3758 PMID: 2609545 Document Number: 341445
The results of radiation treatment for cervical cancer obtained at the Institute Clinic are discussed. Modification-free irradiation was given to 205 patients. Five-year survival was 94 +/- 4% in stage I, 83 +/- 3%--II and 38 +/- 9% in stage III tumor. Dimethylsulfoxide was administered to prevent radiation injury in 48 patients. Radiation injury to the bladder and rectum was observed in 4.9% of cases for each site whereas in controls the indexes were 6.3 and 13.6%, respectively. In 84 patients, dimethylsulfoxide was used in combination with metronidazole to potentiate radiation damage to tumor. This was followed by a significantly more rapid regression of neoplasms. Two-year survival rate in cases receiving topical treatment with both drugs was 75% while in controls--43%.