In vitro effect of psychotropic drugs on the activity of leukocyte elastase

Androsova, L.V.; Shmakova, A.A.

Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 114(3): 55-57

2014


ISSN/ISBN: 1997-7298
PMID: 24781228
Document Number: 677363
To investigate the effect of the neuroleptic aminazine (chlorpromazine) and the antidepressant melipramine on the activity of leukocyte elastase (LE). The LE activity was measured on a spectrophotometer. Different doses of aminazine and melipramine in terms of therapeutic doses were added to the pooled blood serum sampled from 7 healthy people. Aminazine and melipramine inhibited the LE activity. The dose-dependent inhibiting effect of aminazine and melipramine was shown.

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