In vitro effect of psychotropic drugs on the activity of leukocyte elastase
Androsova, L.V.; Shmakova, A.A.
Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 114(3): 55-57
2014
ISSN/ISBN: 1997-7298 PMID: 24781228 Document Number: 677363
To investigate the effect of the neuroleptic aminazine (chlorpromazine) and the antidepressant melipramine on the activity of leukocyte elastase (LE). The LE activity was measured on a spectrophotometer. Different doses of aminazine and melipramine in terms of therapeutic doses were added to the pooled blood serum sampled from 7 healthy people. Aminazine and melipramine inhibited the LE activity. The dose-dependent inhibiting effect of aminazine and melipramine was shown.