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Effect of psychotropic drugs on the structure and function of the adrenal glands of control and stressed animals

Kresiun, V.I.; Rozhkovskiĭ, I.V.

Problemy Endokrinologii 38(3): 41-44

1992

ISSN/ISBN: 0375-9660
PMID: 1513792
Document Number: 404422
The purpose of the experiment was to investigate the structure and function of the rat adrenal glands under chronic stress and its correction. Chronic stress is known to cause hypertrophy of the adrenals, enlargement of the area of nuclei and width of the cortical and medullary layers, a decrease in the content and pathological distribution of phospholipids, ascorbic acid and neutral lipids reflecting the function of these glands. Preventive courses of litonit, pikamilon and, to a lesser degree, piracetam and relanium weakened or removed characteristic pathomorphological changes in the adrenal structure. Complex analysis of the extracerebral mechanisms of each drug revealed the highest preventive activity of litonit which can be used to correct the adrenal glands under chronic stress.

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