Insulin-like growth factor 1-induced changes in hemoporphyrin conformation in hemoglobin and NO-transporting function in human erythrocytes

Kovalenko, S.S.; Parshina, E.I.; Iusipovich, A.I.; Maksimov, G.V.; Rubin, A.B.

Biofizika 59(6): 1093-1096

2014


ISSN/ISBN: 0006-3029
PMID: 25715614
Document Number: 675723
The evidence on the effect of different insulin-like growth factor concentrations on a state of human erythrocytes is provided. Activation of the insulin-like growth factor receptors led to changes in the conformation of hemoglobin, NO-transporting function in erythrocytes and also in micro-viscosity of the cell membrane. It was shown for the first time that at the binding of the insulin-like growth factor to a cell surface, hemoglobin of erythrocytes alters its conformations and affinity to ligands.

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