The generalized Shwartzman reaction in pigs induced by diet and single injection of disintegrated cells or partially purified endotoxin from Escherichia coli
Teige, J.; Nordstoga, K.; Fjolstad, M.; Nafstad, I.
Acta Veterinaria Scandinavica 14(1): 92-106
1973
ISSN/ISBN: 0044-605X PMID: 4580958 Document Number: 67301
Pigs were fed a diet supplemented with either cod liver oil, or cod liver oil plus vitamin E; or commercial pig food. After one injection of disintegrated cells, lesions characteristic for generalized Shwartzman reaction (GSR), including haemorrhagic necrosis of the skin, developed in the two groups given cod liver oil. A single case was also recorded among the control pigs after injection of a large dose. One injection of partially purified endotoxin gave almost similar results. Hence pigs fed relatively high amounts of unsaturated fat are predisposed for the GSR, and vitamin E may provide some protection against the development of the reaction.