Physiologic and pathologic changes in calves given Escherichia coli endotoxin or Pasteurella multocida
Musa, B.E.; Conner, G.H.; Carter, G.R.; Gupta, B.N.; Keahey, K.K.
American Journal of Veterinary Research 33(5): 911-916
1972
ISSN/ISBN: 0002-9645 PMID: 4553996 Document Number: 53199
The inoculation of Escherichia coli endotoxin or Pasteurella multocida organisms into calves elicited nearly the same physiological and pathological responses, indicating that a substance identical to, or nearly identical to, coli endotoxin was released into the tissues during the course of multocida infection. After either of the two treatments, pulmonary hyperaemia, oedema, and interstitial pneumonia were the most prominent changes. In the group given coli endotoxin, blood cholesterol concentrations felt both initially and after 5 hours. Calves given multocida organisms showed an initial decrease as well as a decrease at the end of a 26-hour period. At the 5th hour of endotoxic shock or at the 26th hour after multocida inoculation, there was a tendency for blood glucose concentrations to decrease. The concentrations of serum glutamic oxalacetic transaminase were characteristically increased at the 5th hour endotoxic shock, whereas the concnetrations of serum glutamic pyruvic transaminase were characteristically increased at the 26th hour after multocida inoculation.