The effects of Escherichia coli endotoxin in calves
Wray, C.; Thomlinson, J.R.
Research in Veterinary Science 13(6): 546-553
1972
ISSN/ISBN: 0034-5288 PMID: 4567733 Document Number: 44583
Varied doses of endotoxin were administered to calves by intravenous, subcutaneous and oral routes. The dosage necessary to produce clinical signs and death differed considerably in individual calves. Susceptibility to endotoxin did not correlate directly with the presence or absence of circulating antibodies. The gross and histological resembled those which occur in natural and experimental colibacillosis, and bore a close resemblance to those described in calves in association with anaphylactic shock. It is postulated that hypersensitivity and anaphylaxis may play a part in the pathogenesis of colibacillosis in calves.