Protein-synthesizing function of neutrophils and lipid-releasing ability of leukocytes in patients with atherosclerosis
Mishlanov, V.I.; Sandakov, P.I.; Ronzin, A.V.; Vladimirskii, V.E.; Syromiatnikova, L.I.; Polovinkina, T.A.; Seredenko, N.N.; Kharuzina, O.V.; Mishlanova, S.L.
Klinicheskaia Meditsina 91(12): 17-20
2013
ISSN/ISBN: 0023-2149 PMID: 25702424 Document Number: 671345
Concentrations of defensins-alpha, lipoprotein(α), C-reactive protein, proBNP, VII- coagulation factor and von Wilebrandt factor were measured in supernatants of 3-day leukocyte cultures enriched with neutrophils in order to estimate their synthesis in patients with stable angina and atherosclerosis of lower extremities. In addition, in vitro tumor necrosis factor-alpha test was performed. Simultaneously, concentrations of serum interleukine-6, -8, defensins-alpha, C-reactive protein, proBNP, VII-coagulation factor were determined. Neutrophil protein synthesis was impaired in the patients with stable angina. The same was true of defensins-alpha synthesis whereas production of lipoproteins, pro-BNP, C-reactive proteins, IL-8, and von Wilebrandt factor increased. Pathogenetic role of TNF-alpha was demonstrated.