Computational study of the interplay of adhesion and chemotaxis in the cell seeding of tissue engineering scaffolds with incorporated chemoattractants
Robu, A.; Stoicu-Tivadar, L.; Neagu, A.
Studies in Health Technology and Informatics 192: 1141
2013
ISSN/ISBN: 0926-9630 PMID: 23920915 Document Number: 670764
Cell migration is important in embryogenesis, metastasis and wound healing. Often, morphogenesis involves chemotactic cell movement up or down chemical gradients. We have developed a computational model of a cell suspension in the vicinity of a porous scaffold that incorporates a chemoattractant substance. In order to study the interplay of adhesion and chemotaxis on cell seeding , we developed a computational model of the system and simulated its evolution using a Metropolis Monte Carlo algorithm. We varied the chemotactic strengths of the cells in order to identify the optimal conditions for a rapid and uniform seeding.