Bioinformatics on new human adenoviruses causing nosocomial infection
Aoki, K.; Kaneko, H.; Kitaichi, N.; Watanabe, H.; Ishida, S.; Ohno, S.
Nippon Ganka Gakkai Zasshi 117(9): 721-726
2013
ISSN/ISBN: 0029-0203 PMID: 24261186 Document Number: 669661
Human adenovirus (HAdV) causing epidemic keratoconjunctivitis is limited to D and E species. Recent progress in bioinformatics revealed that these viruses attach to the host with fibers, infiltrate the host cells via RGD (Arg-Gly-Asp) motif of penton base, and reveal their serological reaction by hexons. Loops 1 and 2 are the variable regions of each hexon. The possibility that a novel adenovirus later named HAdV-52 was transmitted over the wall of species' from monkeys to humans was reported. The recombination of the above three hot spots introduces novel types such as HAdV-53, -54, and -56. Boinformatics may provide rapid genotyping in nosocomial infection, predicting future epidemics, and an estimate of the therapeutic target molecules in the near future.