Oncolytic properties of some orthopoxviruses, adenoviruses and parvoviruses in human glioma cells
Razumov, I.A.; Sviatchenko, V.A.; Protopopova, E.V.; Kochneva, G.V.; Kiselev, N.N.; Gubanova, N.V.; Shilov, A.G.; Mordvinov, V.A.; Netesov, S.V.; Chumakov, P.M.; Loktev, V.B.
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 12: 4-8
2013
ISSN/ISBN: 0869-6047 PMID: 24741936 Document Number: 667835
Currently one of the most promising approaches in development of cancer virotherapy is based on the ability of oncolytic viruses to selective infection and lysis of tumor cells. The goal of the study was to identify and evaluate perspective oncolytic viruses capable of selectively destroying human glioma cells. Original GB2m, GA14m and GB22m glioma cell cultures derived from patients were used for evaluating in vitro oncolytic activity of some typical orthopoxviruses, adenoviruses and parvoviruses. The oncolytic activity in the human glioma cell models was confirmed for LIVP and WR strains of vaccinia virus, Adel2 and Ad2del strains with deletions within E1B/55K gene and derived from human adenoviruses type 2 and 5, respectively. We consider these oncolytic viruses as promising agents for the treatment of human malignant glioma.