Pathogenesis of skin injury in immunodeficient rats
Shukhtin, V.V.; Hozhenko, A.I.; Levyts'kyĭ, A.P.
Fiziolohichnyi Zhurnal 59(4): 63-66
2013
ISSN/ISBN: 2522-9028 PMID: 24175478 Document Number: 669340
We investigated the skin condition in rats with immunodeficit induced by cyclophosphane. Cyclophosphane induced in the blood the development of two phases pathological process. The first leukopenic phase is mediated by the action ofcytostatics, and the second hyperleucocytic phase is induced by liver injury and splenomegalia. Dysbiosis and inflammation are developed in the skin, especially during the second phase.
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