The skin trichophytin reactivity in psoriasis vulgaris. a contribution to the pathogenesis and clinical aspects of psoriatric skin changes
Weigel, B.A.
Zeitschrift für Hautkrankheiten 53(9): 291-302
1978
ISSN/ISBN: 0301-0481 PMID: 654403 Document Number: 134682
On the basis of the resultats of four years lasting studies on 330 patients with psoriasis the allergic mechanism of the dermatosis is discussed. In 65 cases it was able to make a clinical diagnosis of the primary psoriasis focus (PPH) and to cultivate from it in 12 cases trichophyton fungi. The possibility to show the relevant mycotic antigen from the PPH is demonstrated, the development of the disease from the initial focus is described by analogy to the clinical development and a difference is made between the acute--subacute psoriasis and the chronic psoriasis with regard to the responsiveness of the competent immunological system. With 330 patients intracutan-tests have been made with trichophytin, and at the same time control tests with tuberculin, toxoplasmin and candida alb. for a period of 12 months up to 24 months. The relative and even absolute blocking of the trichophyton immunological system (TAS) and which is in correlation to the pushes and remittences of the disease constitutes the impressing resultat of the tests. With regard to the working mechanism the opinion is held that the immunological complex which is existant in the psoriatic epidermis participates to a great extent in the release of the epidermopoesis which is typical for the psoriasis. The classification into the stade of PS I (early psoriasis), PS II and PS III (late psoriasis) makes the differentiation of the process possible.