An unusual case of mycosis fungoides with high proliferation index and C-MYC/8q24 translocation
Feng, Z.; Zhou, J.; Bentley, G.
Journal of the Louisiana State Medical Society Official Organ of the Louisiana State Medical Society 165(6): 324-328
2013
ISSN/ISBN: 0024-6921 PMID: 25073258 Document Number: 669341
Mycosis fungoides is the most common entity among all cutaneous T cell lymphomas. Herein, we report for the first time a case of mycosis fungoides in a 51-year-old man with aggressive clinical course and confirmed C-MYC/8q24 translocation. Review of the literature reveals that dermal Ki-67 proliferation index not only correlates with the type and extent of skin involvement and clinical stage, but is also an independent adverse prognostic factor. Mycosis fungoides is associated with multiple genomic abnormalities, particularly in patients with tumor stage and advanced clinical stage, and gain of C-MYC/8q24 is associated with a shorter survival. Our patient showed a high dermal Ki-67 level and concomitant C-MYC/8q24 translocation, which may account for the aggressive clinical course and refractoriness to CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy.