Metabolic syndrome and cognitive dysfunction in the old age
Parnowski, T.; Kałuza, B.
Psychiatria Polska 47(6): 1087-1099
2013
ISSN/ISBN: 0033-2674 PMID: 25007540 Document Number: 667780
We analyzed metabolic profile of patients with cognitive dysfunctions by means of levels of lipoproteins, glycaemia and hypertension. In naturalistic, open manner, we studied 100 persons--44 without cognitive dysfunctions, 17 with MCI and 39 with dementia. Patients were grouped according to ICD-10, NIA/AA, McKhann's criteria of cognitive impairment and STMS cutoff levels. We found correlations between HDL cholesterol (p = 0.036, OR = 1.061, <0.99; 1.13>), hyperglycaemia (p = 0.008, OR = 0.97, <0.95; 0.99>), metabolic syndrome (p = 0.03; OR = 0.34; <0.12; 0.91>) with age (p = 0.001; OR = 0.9; <0.84; 0.95>) and dementia. We confirmed also correlations of glucose levels with CT changes (p = 0.01, OR = 0.97, <0.95; 0.99>), and age (r = -0.47, p = 0.000001), fasting glucose (r =-0.33, p = 0.0024), HDL levels (r = 0.32; p = 0.05) with STMS results. Metabolic-cognitive syndrome seems to be a part of pathogenesis of dementia.