Association Between Components of Metabolic Syndrome and Cognitive Dysfunction: Cross-Sectional Study Among the Population of the Turkestan Region
Madenbay, K.; Shalkharova, Z.; Shalkharova, Z.; Nuskabayeva, G.; Sadykova, K.
Georgian Medical News 2018(278): 114-120
2018
ISSN/ISBN: 1512-0112 PMID: 29905556 Document Number: 696403
Metabolic syndrome (MetS) being a risk factor for many vascular pathologic processes is associated with cognitive dysfunction with vascular genesis. Objective - to study the relationship between clinical and metabolic indicators and the presence of cognitive dysfunction in persons with MetS. A transverse study was conducted in the Turkestan region of Southern Kazakhstan during which a general clinical, laboratory examination and evaluation of cognitive function was performed in 639 patients. To assess the relationship between the MetS, its individual components and cognitive function with Mini Mental State Examination test (MMSE) multinominal logistic regression analysis was used. According to the MMSE test, signs of cognitive impairment were revealed in 4.1% of the examined. A statistically significant positive association was found between the chances of having cognitive impairment andMetS, systolic hypertension, diastolic hypertension, hypercholesterolemia, hyperglycaemia. Our results showed that the components of MetS correlate with cognitive impairment. Further research should be directed towards determining the impact of early detection and treatment of metabolic syndrome on cognitive ability.