The estimation of glomerular filtration rate in type 2 diabetic patients may depend on the equation used
Fabbian, F.; Pala, M.; Monesi, M.; De Giorgi, A.; Mallozzi Menegatti, A.; Tomasi, F.; Portaluppi, F.; Manfredini, R.
European Review for Medical and Pharmacological Sciences 17(20): 2791-2797
2013
ISSN/ISBN: 1128-3602 PMID: 24174362 Document Number: 666933
The aim of this study was to compare the estimation of glomerular filtration rate (GFR) in type 2 diabetes mellitus (DM) outpatients. The study included 1686 subjects, aged 68±10 years. GFR was evaluated with five different equations: GFRMDRD186, GFRMDRD175, GFRCKD-EPI, GFRMAYO, GFRC-G. GFR was lower than 60 ml min-1 kg-1 in 456 patients (27%) by GFRMDRD186, in 531 (31.5%) by GFRMDRD175, in 504 (30%) by GFRCKD-EPI, in 433 (26%) by GFRC-G, and in 255 (15%) by GFRMAYO. The mean differences in measuring GFR with the different formulae ranged from 1.03±6.20 to -14.5±11.9 ml min-1 1.73 m2-1. The evaluation of GFR with different formulae in type 2 DM patients may identify different chronic kidney disease (CKD) stages. Physicians could take advantage by the knowledge of the formula used for evaluation of renal function, for a better interpretation of values and a more appropriate use in the everyday clinical practice.