Estimating glomerular filtration rate in Asian patients with chronic kidney diseases from bioelectrical impedance analysis
Satirapoj, B.; Supasyndh, O.; Patumanond, J.; Choovichian, P.
Journal of the Medical Association of Thailand 89(10): 1584-1591
2006
ISSN/ISBN: 0125-2208 PMID: 17128831 Document Number: 2634
Background. Estimation of glomerular filtration rate (GFR) is usually determined from 24-hour urine collection, but it is time-consuming, and difficult in clinical practice. The authors attempted to select an accurate and safe, but more convenient test to obtain an estimated GFR.Objective: To compare estimation of GFR by Bioelectrical impedance analysis (BIA) with GFR calculated by 24-hour urine averaged creatinine clearance and urea clearance (Ccr-Cu-GFR).Material and Method. The authors examined 79 non-diabetic chronic kidney disease (CKD) patients that had estimated GFR between 15 and 89 ml/min/1.73 ml. Subjects were categorized into three subgroups according to K/DOQI-CKD classification: GFR of 60-89 ml/min/1.73m(2) (stage 2, 5 subjects), 30-59 ml/min/1.73ml (stage 3, 31 subjects), and 15-29 ml/min/1.73m(2) (stage 4, 43 subjects).Results: The mean value of Ccr-Cu-GFR was 33.79 +/- 14.78 ml/min/1.73 m(2) and GFR by BIA (BIA-GFR), 34.63 +/- 14.86 ml/min/1.73 m(2) with no overall statistical differences (p = 0.838). In stage 3 CKD patients, the mean BIA-GFR and Ccr-Cu-GFR were similar (38.84 +/- 12.47 vs 41.16 +/- 9.17, p = 0.399) while in stage 2 CKD, BIA-GFR tended to underestimate (63.50 +/- 19.35 vs 70.94 +/- 7.82, p = 0.407) and in stage 4 CKD, BIA-GFR significantly overestimated Ccr-Cu-GFR (27.31 +/- 9.11 vs 23.76 +/- 5,68, p = 0.040).Conclusion: The findings suggest that BIA-GFR in non-diabetic CKD patients closely resembled with Ccr-Cu-GFR especially in stage 3 CKD patients. BIA-GFR may be considered as a more convenient test for an assessment of GFR in non-diabetic CKD patients.
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