Glomerular filtration rate is an indicator of endothelial function at early stages of chronic kidney disease
Smirnov, A.V.; Petrishchev, N.N.; Panina, I.I.; Rumiantsev, A.S.; Degtereva, O.A.; Tugusheva, F.A.; Menshutina, M.A.
Terapevticheskii Arkhiv 79(6): 25-30
2007
ISSN/ISBN: 0040-3660 PMID: 17684962 Document Number: 614639
To study effects of glomerular filtration rate (GFR) reduction on endothelial function in patients at early stages of chronic renal kidney (CKD). Endothelial function of 101 patients with CKD of stage I-III was examined using reactive hyperemia test, dopplerography of skin vessels with ionophoresis of acetylcholin and nitroglycerin, lipidogram parameters, homocistein and annexin A5 levels, intima-media complex thickness of the common carotid artery, echocardiography findings. Cardiovascular complications risk factors were found in all the patients: increased body mass index, arterial hypertension, dyslipoproteinemia, hyperhomocysteinemia. Reduced GFR (under 90 ml/min) is an independent factor of atherosclerosis risk. GFR reduction corresponding to CRD of stage II is accompanied with enhancement of apoptosis and development of vasomotor endothelial dysfunction that in combination with risk factors contribute to development of a preclinical atherosclerosis phase.