JAK inhibitor
Yamaoka, K.; Tanaka, Y.
Nihon Rinsho. Japanese Journal of Clinical Medicine 71(7): 1243-1247
2013
ISSN/ISBN: 0047-1852 PMID: 23961674 Document Number: 666869
Biologics targeting inflammatory cytokine has become a standardized tool for remission induction in rheumatoid arthritis (RA). However, it is handled under restricted conditions and their cost of acquisition is high. Small molecule drugs targeting Janus kinase (JAK), a molecule involved in intracellular signaling pathway has shown similar treatment effect as biologics. Moreover, inhibitory effect on bone destruction has been demonstrated and has been approved in 2012 as a new disease modifying anti-rheumatic drug in USA. However, since the inhibition of JAK results in inhibition of multiple cytokine signaling pathways, the clinical studies have also shown adverse events differing from biologics.