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Blood platelet plasminogen activator inhibitor: two different pools of endothelial cell type plasminogen activator inhibitor in human blood

Sprengers, E.D.; Akkerman, J.W.; Jansen, B.G.

Thrombosis and Haemostasis 55(3): 325-329

1986

ISSN/ISBN: 0340-6245
PMID: 3092389
Document Number: 278205
An assay for plasminogen activator inhibitor in human platlets is described. With this assay we find an average value of 6.8 .times. 10-8 IU/platelet (S.D. = 3.0 .times. 10-8; n = 20) in a healthy population. We characterized the PA-inhibitor from platelets and identified it as endothelial cell type plasminogen activator inhibitor, by its immunologic and functional properties. Besides the plasma pool of plasminogen activator inhibitor with a very high turnover rate, platelets constitute a second pool of plasminogen activator inhibitor in the circulation of the same order of magnitude. The two different pools of plasminogen activator inhibit might have a different physiologic function.

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