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Identification of osteogenic signal and the development of artificial bones

Ohba, S.; Chung, U.-i.; Tei, Y.

Clinical Calcium 23(12): 1723-1729

2013

ISSN/ISBN: 0917-5857
PMID: 24292526
Document Number: 666355
Mammalian skeletons are formed through two distinct processes, intramembranous ossification and endochondral ossification. During the endochondral ossification, indian hedgehog (Ihh) /parathyroid hormone-related protein (PTHrP) negative-feedback loop regulates the distance between epiphysis and the layer of hypertrophic chondrocytes. Ihh also stimulates bone formation. Based on such knowledge, bioactive molecule-loaded artificial bones are expected to achieve efficient bone regeneration without cell transplantation.

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