Neuro-pharmacological potentials of Buchholzia coriacea (Engl.) seeds in laboratory rodents
Onasanwo, S.A.; Obembe, O.O.; Faborode, S.O.; Elufioye, T.O.; Adisa, R.A.
African Journal of Medicine and Medical Sciences 42(2): 131-142
2013
ISSN/ISBN: 0309-3913 PMID: 24377198 Document Number: 664495
Buchholzia coriacea, taken by elderly, has phytochemicals that have neuro-active metabolites, and the folklore documented its use in neuro-behavioural despairs. This study was conducted to investigate the neuro-pharmacological potentials of Buchholzia coriacea (MEBC) seed extract in the laboratory rodents. Methanol extract of the seeds on B. coriacea (MEBC) was evaluated for its antidepressant (Forced Swimming Test and Tail Suspension Test), anxiolytic (Light-Dark Test, Hole Board Test and Elevated Plus Maze), antinociceptive (Hot-Plate and Tail Flick test) and motor coordination (Rota Rod) functions in mice. Our findings showed antidepressant activity (P < 0.05) of MEBC that is dose-dependent. Secondly, MEBC showed significant anxiolytic property that is comparable with the standard drug (diazepam). Furthermore, MEBC significantly prolonged the latency on hot-plate and tail flick responses when compared with the control (P < 0.05). Finally, MEBC significantly prolonged mice endurance time (P < 0.05) on a revolving Rota rod. The results suggest antidepressant, anxiolytic and analgesic potentials of MEBC. Buchholzia coriacea may have a stabilizing effect on the motor activity and MEBC probably contains secondary metabolites with some therapeutic effects on neuro-physiological disorders like depression, anxiety and pain.