Ion-pair HPLC analysis of B vitamins in syrup products in Indonesia
Miyazaki, T.; Horisaki, T.; Aso, Y.; Okuda, H.
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo Hokoku 131: 58-65
2013
ISSN/ISBN: 1343-4292 PMID: 24340671 Document Number: 664023
A training course for analysis of B vitamins in syrup products was undertaken at the National Agency of Drug and Food Control at Jakarta as part of the project to deliver safe drugs to people in Indonesia by Japan International Cooperation Agency. Analytical methods have been developed for quantitative determination of B vitamins by ion-pair high-performance liquid chromatography using 1-hexanesulfonic acid sodium salt. Measurements were performed for two syrup products removed from a drug store in Jakarta to determine the amount of each vitamin B. The measured values of riboflavin 5'-phosphate sodium, nicotinamide and pyridoxine hydrochloride were almost the same with those of nominal content for both products. While the measured values of thiamine hydrochloride, pantothenol and cyanocobalamin were approximately twice the amount of nominal contents.