Ionizing radiation-induced DNA damage and repair
Tashiro, S.; Sun, J.
Nihon Rinsho. Japanese Journal of Clinical Medicine 70(3): 383-387
2012
ISSN/ISBN: 0047-1852 PMID: 22514912 Document Number: 663905
Ionizing radiation has been shown to induce various types of chromosomal DNA damages. Among these DNA damages, DNA double strand breaks(DSBs) are the most severe damages resulting in cell death or chromosome abnormalities. Proteins associated with DNA repair, such as phosphorylated form of histone H2AX, a histone variant of H2A, and a DNA recombinase RAD51, has been shown to form radiation-induced repair foci at sites containing DNA damage. Reorganization of damaged chromatin by protein modifications or exchange of histones has been shown to play an important role in the formation of radiation induced repair foci.