Relationship between specific immunocyte and pseudoanaphylactoid reactions induced by Shuanghuanglian injection
Yi, Y.; Liang, A.; Li, C.; Zhao, Y.; Wang, Y.; Li, G.
Zhongguo Zhong Yao Za Zhi 37(13): 1898-1900
2012
ISSN/ISBN: 1001-5302 PMID: 23019866 Document Number: 663413
To investigate the relationship between specific immunocyte and pseudoanaphylactoid reactions (PR) induced by Shuanghuanglian injection (SHLI). ICR mice, SCID mice and BALB/C athymic mouse were divided into different test groups, the mice were intravenously injected with solutions of different concentration of SHLI, positive control Compound 48/80 and normal sodium. All test substances were mixed with 0. 4% Evans blue. The reaction and vascular permeability of the ears were observed and measured 30 min after SHLI injected. SHLI of 300, 600 mg x kg(-1) caused obvious vascular hyperpermeability in ICR mice, but the same dose of SHLI didn't cause vascular hyperpermeability in SCID mice and BALB/C athymic mouse. SHLI in equivalent and 2 times the clinical dose can cause PR in ICR mice, but the same dose of SHLI can't cause PR in SCID mice and BALB/C athymic mouse, so specific immunocyte maybe take part in the SHLI-induced PR.