Neutralization activity and kinetics of two broad-range human monoclonal IgG1 derived from recombinant Fab fragments and directed against Hepatitis C virus E2 glycoprotein
Diotti, R.A.; Sautto, G.A.; Solforosi, L.; Mancini, N.; Clementi, M.; Burioni, R.
New Microbiologica 35(4): 475-479
2012
ISSN/ISBN: 1121-7138 PMID: 23109015 Document Number: 662859
Hepatitis C virus (HCV) is the major cause of chronic liver disease worldwide. There is evidence that neutralizing anti-HCV antibodies may find potential applications in novel prophylactic and therapeutic strategies. This paper describes the very high neutralization activity and unique biological features of two broadly cross-reactive and cross-neutralizing anti-HCV human monoclonal IgG1 derived from human monoclonal recombinant Fab fragments.
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