MiRNAs in cartilage development
Asahara, H.
Clinical Calcium 22(5): 653-657
2012
ISSN/ISBN: 0917-5857 PMID: 22549189 Document Number: 661535
MicroRNAs (miRs) are - 22 nucleotide non-cording forms of RNA and exhibit tissue or developmental stage specific expression patterns. Recent findings show taht the expression of miR-140, which is specifically expressed in chondrocytes, is reduced in OA chondrocytes. Furthermore, knockdown of miR-140 in mice chondrocytes promotes arthritis in mice. In addition to this, several other miRs have also been shown to play important roles in chondrocytes. Thus, miRs should be critical factors for cartilage development and homeostasis.