Verification of histologic diagnosis in cervical carcinoma in situ with contradictory morphological data
Novik, V.I.
Voprosy Onkologii 58(2): 227-232
2012
ISSN/ISBN: 0507-3758 PMID: 22774529 Document Number: 660720
The medical technology of in situ cervical carcinoma cytological verification using computer-assisted morphometric and density analysis of atypical cells nuclei was developed. The technology is aimed at diagnosis verification in cases with contradictory morphological data. The malignant transformation of cervical epithelium undetectable by conventional morphology methods can be diagnosed using the Felgen-stained samples nuclear DNA distribution data. The right DNA distribution diagram shift with modal class 4C or higher, mean DNA contents higher than 4C, the ratio between aneuploidic and polyploidic cells higher than 0.2 are the signs of cervical epithelium malignant transformation.