Clinico-morphological diagnosis of adenocarcinoma in situ of the cervix uteri
Sidoruk, A.A.; Novik, V.I.; Urmancheeva, A.F.
Voprosy Onkologii 55(6): 733-739
2009
ISSN/ISBN: 0507-3758 PMID: 20210017 Document Number: 630854
Clinical and morphological investigation involved 57 patients with adenocarcinoma in situ of the cervix uteri (poorly-differentiated (precancerous) cell carcinoma in situ (PAIS)--30; adenocarcinoma in situ (AIS)--27). Morphometric measurements using microimaging technique were carried out on 31 cytological patterns. Clinical symptoms appeared non-specific. Cytological examination of smears detected tumor cells in all patients. Predictions for PAIS histotype were confirmed in 83%, cytological findings--78%; AIS--52% and 58%, respectively. Accuracy for PAIS and AIS biopsy was 52% and 32%, respectively. The most accurate data were obtained by histological examination of resected material. However, our procedure failed to detect malignant process in 17.5% (PAIS--6 cases and AIS--4) which was established by use of smears (Feulgen).