Toxicological and sanitary characteristics of fullerene C60 administered to the rat gastrointestinal tract
Shipelin, V.A.; Arianova, E.A.; Trushina, E.N.; Avren'eva, L.I.; Batishcheva, S.I.; Cherkashin, A.V.; Soto, S.K.; Lashneva, N.V.; Gmoshinskiĭ, I.V.; Khotimchenko, S.A.
Gigiena i Sanitariia 2: 90-94
2012
ISSN/ISBN: 0016-9900 PMID: 22834278 Document Number: 660022
A four-week experiment dealing with the intragastric administration of fullerene C60 dispersion to rats has established that this substance in a dose of 1 to 10 mg/kg body weight causes a number of changes in the parameters of animals, such as reductions in relative liver weight and isoform CYP 1A2 activity and increases in glutathione reductase activity, eosinophils, and neutrophils. It is concluded that fullerene can affect the animals when orally given in the doses studied.