Nutritional and toxicological impacts of administered inorganic tin for six months in rats
Fritsch, P.; de Saint-Blanquat, G.; Derache, R.
Toxicological European Research. Recherche Europeenne en Toxicologie 1(4): 253-261
1978
ISSN/ISBN: 0249-6402 PMID: 741482 Document Number: 131631
An experimentation of intoxication by stannous chloride has been realized in the rat. Two groups of animals have been fed ad libitum, during six months, with a diet containing respectively 0,4 and 0,8 g of tin (SnCl2) for 100 g of dry food. By gamma radioactivity measurements (with 113Sn used as a tracer), it results that this metal does not practically clear the digestive barrier. All the treated animals are characterized by a ponderal evolution obviously lower than temoins. At the end of treatment, tin entails a significative diminution of hematocrit, hemoglobin and serous iron, particularly at the highest dose studied. The essential impact remains that tin induces a total irritation of gastro-intestinal tract, proved by histological investigations.