Dissolution studies and quantification of meloxicam in tablet dosage form by spectrophotometry
Induri, M.; Mantripragada, B.R.; Yejella, R.P.; Kunda, P.R.; Nannapaneni, D.T.; Boddu, R.
Pakistan Journal of Pharmaceutical Sciences 25(1): 283-287
2012
ISSN/ISBN: 1011-601X PMID: 22186342 Document Number: 658921
Two simple and inexpensive UV spectrophotometric methods were developed for the quantification and dissolution studies of meloxicam in tablet dosage forms. Meloxicam was estimated at 365nm and 360nm in Method I and Method II, respectively. The calibration curve was linear over a concentration range from 2.0 to 12.0μg/ml for both methods. The limit of detection and limit of quantitation were found to be 0.12μg/ml and 0.38μg/ml, 0.09μg/ml and 0.27μg/ml for Method I and Method II, respectively. The percentage recoveries of meloxicam were found to be 99.68 to 100.61% and 99.11 to 100.96% for Method I and Method II, respectively. It was concluded that the developed methods are precise, accurate and were successfully applied for the estimation of meloxicam in pharmaceutical formulations and in vitro dissolution studies.