Analysis of chemical constituents of chuanxiong rhizoma absorbed into rat brain tissues by UPLC-Q-TOF-MS
Zuo, A.-H.; Cheng, M.-C.; Wang, L.; Xiao, H.-B.
Zhongguo Zhong Yao Za Zhi 37(23): 3647-3650
2012
ISSN/ISBN: 1001-5302 PMID: 23477157 Document Number: 657212
To analyze and identify the chemical constituents in rat brain tissues after oral administration of Chuanxiong Rhizoma extracts. The dosed and blank rat brain tissues were analyzed by UPLC-Q-TOF-MS. Different peaks were observed in total ion chromatograms and then identified according to their retention time, accurate mass weight, MS and MS/MS data. After oral administration of Chuanxiong Rhizoma extracts, 3 compounds were absorbed into rat brain tissues through BBB. They were identified as senkyunolide I, senkyunolide A and ligustilide. The study is helpful for interpreting effective substance of Ligusticum chuanxiong.