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Analysis of chemical constituents of chuanxiong rhizoma absorbed into rat brain tissues by UPLC-Q-TOF-MS

Zuo, A.-H.; Cheng, M.-C.; Wang, L.; Xiao, H.-B.

Zhongguo Zhong Yao Za Zhi 37(23): 3647-3650

2012

ISSN/ISBN: 1001-5302
PMID: 23477157
Document Number: 657212
To analyze and identify the chemical constituents in rat brain tissues after oral administration of Chuanxiong Rhizoma extracts. The dosed and blank rat brain tissues were analyzed by UPLC-Q-TOF-MS. Different peaks were observed in total ion chromatograms and then identified according to their retention time, accurate mass weight, MS and MS/MS data. After oral administration of Chuanxiong Rhizoma extracts, 3 compounds were absorbed into rat brain tissues through BBB. They were identified as senkyunolide I, senkyunolide A and ligustilide. The study is helpful for interpreting effective substance of Ligusticum chuanxiong.

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