Multiple endocrine neoplasia type 1
Salmela, P.I.
Duodecim; Laaketieteellinen Aikakauskirja 128(22): 2345-2354
2012
ISSN/ISBN: 0012-7183 PMID: 23342481 Document Number: 656775
Multiple endocrine neoplasia type 1 (MEN1) is a complex multisystem disease characterized by the combined occurrence of endocrine tumours of the parathyroid glands, anterior pituitary gland and adrenal glands and the neuroendocrine tumours (NET) of duodenum, pancreas, thymus and bronchus. Malignancy occurs commonly (up to 30 %) and malignant NETs are important causes of the MEN1-related morbidity and mortality. Regular clinical, biochemical and radiologic screening for the syndrome-related tumours are the basis of the life-long surveillance. Early detection and adequate management of these tumours reduce risk of death and morbidity.