A case report of multiple endocrine neoplasia type 2b
Ueda, M.; Mizuno, S.; Takeuchi, M.; Imai, T.; Satoh, Y.; Asano, M.; Yoshida, N.; Nozaki, H.; Funahashi, H.; Takagi, H.
Gan no Rinsho. Japan Journal of Cancer Clinics 33(9): 1079-1084
1987
ISSN/ISBN: 0021-4949 PMID: 2887674 Document Number: 297198
A 10-year-old girl was admitted displaying a medullary thyroid carcinoma, accompanying neurinomas of the tongue, marfanoid habitus, megacolon, and scoliosis. Although her adrenal glands were found to be unremarkable on both CT and ultrasonogram examination an MIBG scintiscan showed a 131-1 uptake, suggesting the presence of medullary hyperplasia. Remarkable nodal involvement with invasive features witnessed in the upper mediastinum during tertiary surgery four years later, following a total thyroidectomy. The TCT and CEA profiling was not sufficient enough to predict a recurrence. At the present state there is difficulty in providing an early diagnosis; through node dissection, however, is considered to be necessary at time of primary thyroid operation in cases with MEN type 2b.