Type B1 thymoma in multiple endocrine neoplasia type 1 (MEN-1) syndrome
De Toma, G.; Plocco, M.; Nicolanti, V.; Brozzetti, S.; Letizia, C.; Cavallaro, A.
Tumori 87(4): 266-268
2001
ISSN/ISBN: 0300-8916 PMID: 11693806 Document Number: 533499
Aims and background: Multiple endocrine neoplasia (MEN) syndromes include a group of disorders characterized by the neoplastic transformation of two or more endocrine tissues. In type 1 syndrome (MEN-1), pituitary, parathyroid and pancreatic islet tumors are most frequently represented. Thymic neoplasms are also rarely associated, and thymectomy during subtotal or total parathyroidectomy should always be considered. Study design: The authors describe a rare case of a 22-year-old male who presented a type B1 thymoma without myasthenia gravis associated to hyperparathyroidism, corticoadrenal adenoma and three neuroendocrine pancreatic lesions (somatostatinoma, glucagonoma and insulinoma).