The distribution of iodine-125 labeled alpha-fetoprotein in the animal organism and its accumulation in the tumor
Severin, S.E.; Kulakov, V.N.; Moskaleva, E.I.; Severin, E.S.; Slobodianik, I.I.; Klimova, T.P.
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 4: 11-15
2012
ISSN/ISBN: 0869-6047 PMID: 22834322 Document Number: 656268
The distribution of iodine-125 labeled human alpha-fetoprotein in mice was studied after its intravenous injection. The maximal accumulation of alpha-fetoprotein in different tissues and organs of animals was observed mainly 5 hours after injection. Then the protein was gradually eliminated from the body. In the liver, intestine and blood of intact animals 125I-alpha-fetoprotein persists for at least three days. Accumulation of alpha-fetoprotein in various tissues and organs may determine the different biological effects of this protein. In the mice with transplanted lymphatic leukemia cells P388 the high level of alpha-fetoprotein accumulation was detected in the tumor tissue, reaching 6% of the injected amount per 1 g of tissue. This allows considering the radionuclide-labeled alpha-fetoprotein as a promising medical radionuclide marker for the radiological detection of malignant tumors.